Endocrine Abstracts

A 73-year-old lady presented to our department with a 6-month history of facial hirsutism and frontal hair loss. Her past medical history comprised of type 2 diabetes and hypertension. Initial blood tests showed testosterone 15.9 nmol/l (normal range 0–1.7), SHBG 123.6 nmol/l, LH 23.1 iu/l (normal range 16–64), FSH 33.5 iu/l (normal range 16–64), oestradiol 281 pmol/l (normal <43), mild erythrocytosis, mild hyperbilirubinaemia and HbA1c 56 mmol/mol (normal &...

A 61-year-old female, with a previous history of left nephrectomy for papillary renal cell carcinoma, presented with lethargy. Her initial blood tests revealed an adjusted calcium of 4.26 mmol/l (normal range 2.2–2.6) associated with acute renal impairment (creatinine 432 μmol/l, urea 25 mmol/l) and low PTH of 9 ng/l (normal range 20–75). Following rehydration with IV fluids and IV pamidronate administration, her adjusted calcium normalised to 2.37 mmol/l. The i...

Case history: We report an interesting case of a rare cause of hypopituitarism where our patient presented to the hospital with acute onset headache, vomiting, and feeling generally unwell. Investigations/Results: On routine bloods, he was found to have hyponatremia. On further workup of hyponatremia, he had low morning cortisol which was confirmed as secondary adrenal insufficiency on dynamic function testing. He was also deficient in gonadotrophins alo...

Background: In steroid dependent patients the knowledge of steroid dose change during illness and stress is of paramount importance.Objectives: i) To assess patient’s knowledge of steroid management during acute illness and stressful condition. ii) To evaluate whether there is a relation between patient knowledge and admission with documented adrenal crisis. iii) To improve medical access to information about patients on steroid at Emergency Departm...

Sex hormones are important determinant of body composition. The significant negative correlation between testosterone and obesity, positive correlation between testosterone and muscle mass and that testosterone therapy increases muscle mass in hypogonadal men is well-known.Objectives: To assess the impact of total testosterone (TT) level on body composition in men with T2D.Methods: A cross-sectional study involving men with T2D (<e...

Introduction: Current testosterone replacement therapies have limited acceptability: gels can be messy and risk inadvertent dosing of others; injections are painful; and oral testosterone undecanoate (TU) delivers variable testosterone levels, requires concurrent ingestion of a fatty meal and may produce supraphysiological dihydrotestosterone (DHT) levels1. We present the first human trial of an oral native testosterone preparation formulated to deliver testosterone...